Spermidine Tetrahydrochloride

306-67-2

Spermidine Tetrahydrochloride

Spermidine Tetrahydrochloride•Anti-aging

Structure: Spermidine Tetrahydrochloride structure

CAS: 306-67-2

MF: C10H30Cl4N4

MW: 348.18

Synonymes

N,N'-BIS(3-AMINOPROPYL)-BUTANE-1,4-DIAMINE TETRAHYDROCHLORIDEN,N'-BIS(3-AMINOPROPYL)-1,4-BUTANEDIAMINE 4 H CLN,N'-BIS-(3-AMINOPROPYL)-1,4-DIAMINOBUTANE TETRAHYDROCHLORIDENEURIDINE HYDROCHLORIDENEURIDINE TETRAHYDROCHLORIDEMUSCULAMINE HYDROCHLORIDEMUSCULAMINE TETRAHYDROCHLORIDESPERMINE HYDROCHLORIDE

Utilisation

Spermidine tetrahydrochloride is an endogenous metabolite primarily used as an inhibitor of NOS1, NMDA receptors, GluR, and PLCα in neuroscience research. Concurrently, it serves as an efficient DNA precipitating agent, widely applied in DNA extraction, purification, and surface-enhanced Raman spectroscopy (SERS) analysis.

Spécification

99%+

Description

Aperçu

Spermidine tetrahydrochloride is the tetrahydrochloride salt form of the natural polyamine spermidine and is an endogenous metabolite. As a polyamine, it produces a variety of modulatory effects on the NMDA receptor channel, acting through a specific site on the complex which can cause both agonist and antagonist effects.

EINECS: 206-189-8

Product Categories: Glutamate receptor;Isolabel;co-factor

Caractéristiques

Appearance & Form: White to off-white powder

Melting Point: 310-311 °C (dec.)(lit.)

Density (at 20 °C): 1.01 g/mL

Storage Temperature: room temp

Solubility: H2O: 1 M at 20 °C, clear, colorless

pH (25℃, 1M in H2O): 4.5-7.0

Biological Source: synthetic

Water Solubility: Soluble in water (348.2 g/L at 20°C).

Applications

Based on its biological activity and chemical characteristics, spermidine tetrahydrochloride finds specific applications in the following research and experimental fields:

Neuroscience Research: As a research tool to investigate its inhibitory and modulatory effects on NMDA receptors, NOS1 (neuronal nitric oxide synthase), glutamate receptors (GluR), and phospholipase Cα (PLCα).

Molecular Biology & Genomics:

DNA Precipitation & Purification: Widely used to precipitate DNA from low-salt aqueous buffers, a common step in nucleic acid purification. Specific application examples include: precipitating DNA for flow cytometric analysis from fresh frozen breast cancer tissue, archival tissue of salivary gland, renal and thyroid tumors, and red blood cells of chicken.

DNA Structure Analysis: Used as a reactant in surface-enhanced Raman spectroscopy (SERS) for characterizing abasic sites in DNA duplexes.

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