Nicotinamide

98-92-0

Nicotinamide

Nicotinamide•Anti-aging

Struktur:

CAS: 98-92-0

MF: C6H6N2O

MW: 122.12

Synonyme

NicotinamideForBiochemistryNicotinamideB.P.,U.S.P.Niacinamide/NicotinamideNicotinamide(Niacinamide)Nicotinamide(Niacinamide)Bp/UspNicotinamide,98%Vitamin B3NicotinamidumNIACINAMIDE USP GRANULAR

Verwendung

Nicotinamide (Vitamin B3) is primarily used as an essential vitamin to prevent and treat niacin deficiency disorders such as pellagra, and to support cellular metabolism as a coenzyme component. Furthermore, it has been widely applied in skincare and hair care products for its multiple benefits including moisturizing, oil control, anti-wrinkle effects, and maintaining the health of skin and hair.

Spezifikation

99%+

Beschreibung

Übersicht

Nicotinamide, also known as niacinamide, Vitamin B3, or Vitamin PP, is a water-soluble B vitamin. It is a key component of Coenzyme I (NAD) and Coenzyme II (NADP). In the human body, the nicotinamide moiety participates in reversible hydrogenation and dehydrogenation reactions through these coenzymes, playing a central role as a "hydrogen carrier" in biological oxidation processes. This promotes tissue respiration, biological oxidation, and overall metabolism, which is crucial for maintaining the integrity of normal tissues such as the skin, digestive tract, and nervous system. Deficiency leads to impaired cellular respiration and metabolism, causing pellagra.

EINECS: 202-713-4

Product Categories: Inhibitors;Cosmetics;Vitamin Ingredients;Vitamin series;food additive;Cosmeitc raw materials;Nutritional Supplements;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;vitamin;Other APIs;Biochemistry;Vitamins;Vitamins and derivatives;Miscellaneous Compounds;Aromatics;Nicotine Derivatives;Pharmaceutical intermediates;bc0001

Eigenschaften

Appearance & Form: white powder, Odorless

Melting Point: 128-131 °C(lit.)

Boiling Point: 150-160 °C

Density/Specific Gravity: 1.40

Bulk Density: 360 kg/m3

Storage Temperature: 2-8°C

Solubility: 691 g/l

pH (50g/l, H2O, 20℃): 6.0-7.5

pKa (at 20℃): 3.3

Water Solubility (at 20 ºC): 1000 g/L

LogP (at 21℃): -0.38

Stability: Stable. Incompatible with strong oxidizing agents.

Anwendungen

1. Pharmaceutical Field:

Deficiency Prevention and Treatment: As a vitamin drug, it is mainly used for preventing and treating pellagra, as well as related conditions like stomatitis and glossitis.

Metabolic Support: Participates in the metabolism of proteins and sugars, improving human nutritional status.

2. Feed and Food Industry:

Feed Additive: Extensively used as a feed additive to improve animal nutrition and prevent deficiencies.

Food Additive: Used as a food additive (nutritional fortifier) at doses of approximately 30-80 mg/kg. It has better water solubility than nicotinic acid but tends to form complexes with Vitamin C, which may cause caking.

3. Cosmetics and Personal Care (Major Application Area):

Skincare: Moisturizing and Barrier Repair: Effectively reduces transepidermal water loss, showing excellent synergistic effects with ingredients like hyaluronic acid and glycerol.

Oil Control and Pore Improvement: Helps regulate sebum production, achieving oil control, reduction of blackheads, and acne.

Anti-Aging and Anti-Wrinkle: Exerts anti-wrinkle effects by activating ATP, energizing keratinocytes, and promoting collagen synthesis, and works well in synergy with other anti-aging ingredients.

Auxiliary Sun Protection and Repair: Studies show it can effectively reduce UV-induced photoimmunosuppression, providing auxiliary sun protection.

Skin Brightening and Health: Used in skincare to prevent skin roughness, maintain skin cell health, and promote skin brightening.

Gentleness: Generally gentler than ingredients like Vitamin C, but high-concentration products (e.g., 10%) still require patch testing and should not be used concurrently with highly irritating products like salicylic acid or alpha-hydroxy acids.

Hair Care: Used in hair care to promote scalp blood circulation, nourish hair follicles, promote hair growth, and prevent baldness.

4. Scientific Research and Others:

Used in biochemical research and as a nutrient component in tissue culture media.