Calcium L-Threonate
70753-61-6
Calcium L-Threonate
Calcium L-threonate is a novel calcium salt primarily used as a highly bioavailable calcium supplement for the prevention and treatment of calcium deficiency and osteoporosis . It is also investigated for its potential cognitive-enhancing effects, as the L-threonate component may support synaptic function and brain health .
Übersicht
Calcium L-threonate is the calcium salt of L-threonic acid, an active metabolite of vitamin C . It appears as a white crystalline powder with good water solubility . Once dissociated in the body, the L-threonate component exhibits a significant stimulatory action on vitamin C uptake, prolonging its retention in cells . This mechanism is particularly relevant for bone health, as vitamin C is a marker for osteoblast formation and stimulates procollagen and collagen synthesis, thereby influencing the mineralization process . Pharmacokinetically, human studies demonstrate that calcium from calcium L-threonate is well-absorbed, reaching peak plasma concentration approximately 2 hours after oral administration . It has a low oral toxicity profile, with no adverse effects observed at high doses in animal studies, and is unlikely to have genotoxic or carcinogenic potential as L-threonate is an endogenous compound . Beyond its role in calcium supplementation, research has identified a unique function for the threonate component in the central nervous system. Threonate naturally occurs in cerebrospinal fluid and can be elevated by oral administration . Mechanistic studies in cultured neurons show that threonate directly increases intracellular magnesium concentration, upregulates NMDA receptor expression, boosts mitochondrial membrane potential, and increases functional synapse density . These effects, which are specific to threonate, provide a rationale for its use in research on cognitive function and synaptic health.
EINECS: 615-158-1
Product Categories: Ca (Calcium) Compounds;Classes of Metal Compounds;Typical Metal Compounds
Eigenschaften
Melting point: >300 °C(lit.)
Alpha: 16 º (c=1, H2O)
Refractive index: 15 ° (C=1, H2O)
Storage temp.: Inert atmosphere,Room Temperature
Solubility: DMSO (Slightly), Water (Slightly, Heated)
Form: Powder
Color: Pale Brown
Optical Rotation: [α]20/D +16°, c = 1 in H2O
Water Solubility: Soluble in water. Sparingly soluble in methanol.
Anwendungen
1.Osteoporosis and Bone Health Research: Calcium L-threonate is primarily developed and studied as a calcium supplement for the treatment and prevention of osteoporosis and calcium deficiency . Its design aims to provide a highly bioavailable source of calcium, with preclinical studies indicating it can inhibit bone resorption by osteoclasts . However, it is important to note that research findings are mixed; while some studies highlight its potential to support the mineralization process via vitamin C stimulation, other animal studies have reported that calcium L-threonate, unlike some other calcium salts, did not significantly increase bone mineral density in osteoporotic rat models, a finding that underscores the need for further investigation into its specific efficacy for bone density improvement .
2.Cognitive and Neurological Research: The L-threonate component of this compound has garnered significant interest for its potential neuroactive properties. Research indicates that threonate can cross the blood-brain barrier and directly modulate neuronal function by elevating intraneuronal magnesium levels . This mechanism has been shown to enhance functional synapse density and upregulate key synaptic proteins in cultured hippocampal neurons, effects that are unique to threonate and not seen with other common anions . Consequently, calcium L-threonate is used as a research tool to study synaptic plasticity, learning and memory mechanisms, and potential therapeutic strategies for age-related cognitive decline .
3.Nutritional and Dietary Supplement Research: As a source of both calcium and the bioactive metabolite L-threonate, this compound is utilized in the formulation of dietary supplements. It serves as a functional ingredient where enhanced calcium absorption is desired, and its L-threonate content aligns with research into ingredients that may support overall bone and brain health .
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