Cycloastragenol
84605-18-5
Cycloastragenol
Cycloastragenol is an aglycone derivative of astragaloside IV found in the root of Korean Astragalus membranaceus.
概要
Cycloastragenol (TA-65), a small-triterpenoid purified from the root of an Asian medicinal herb, has currently received particular attention for its potential to regulate transcription of telomerase. TA-65 is capable to increase average telomere length and to decrease the percentage of critically short telomeres and DNA damage in MEFs that harbor critically short telomeres. The effects on telomerase appear to be in common with other triterpenoid saponins (ie, ginsenosides RG1 and Rg3). These compounds at concentrations from 1 to 20 μM were reported to protect against IL-1β-, H2O2-, and tert-butylhydroperoxide-induced senescence in human chondrocytes, endothelial progenitor cells and fibroblasts, respectively.
EINECS: 000-000-0
Product Categories: chemical reagent;pharmaceutical intermediate;palnt extract;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
特性
Melting point: >220°C (dec.)
Boiling point: 617.2±55.0 °C
Density: 1.20
Storage temp.: Refrigerator
Solubility: Chloroform (Slightly), Methanol (Slightly), Pyridine (Slightly)
Form: Solid
Pka: 14.57±0.29
Color: White
用途
1.Neurodegenerative Disease Research: Cycloastragenol is investigated for its neuroprotective effects in Parkinson's disease models, where it improves motor function, gait, and coordination, while reducing total, phosphorylated, and aggregated alpha-synuclein in the hippocampus and neocortex through enhanced autophagy markers . It also shows promise in Alzheimer's disease research by activating telomerase and potentially mitigating pathological tau accumulation .
2.Immunology and HIV Research: In CD8+ T lymphocytes from HIV-1-infected patients, cycloastragenol retards telomere shortening, increases proliferative potential, and enhances cytokine/chemokine production and antiviral activity, suggesting applications in immune restoration and chronic infection management .
3.Aging and Senescence Research: Cycloastragenol functions as a novel senolytic agent, inducing senescent cell apoptosis and restoring physical function in mouse models of irradiation-induced aging . It also protects against IL-1β-, H₂O₂-, and tert-butylhydroperoxide-induced senescence in human chondrocytes, endothelial progenitor cells, and fibroblasts.
4.Cardiovascular and Cerebrovascular Research: Cycloastragenol exhibits anti-ischemic activity without toxicity and protects against myocardial and cerebral ischemia, atherosclerosis, and hypertension through antioxidant, anti-inflammatory, and anti-apoptotic mechanisms involving PI3K/Akt and Nrf2/HO-1 pathways .
5.Pulmonary Fibrosis Research: In a murine model of idiopathic pulmonary fibrosis, cycloastragenol suppresses lung damage, indicating potential therapeutic applications in fibrotic lung diseases .
6.Signal Transduction and Molecular Mechanism Studies: Cycloastragenol serves as a tool compound for studying the Src/MEK/ERK signaling pathway, demonstrating ERK phosphorylation in multiple cell types including fibroblasts, keratinocytes, and cells of lung, brain, mammary, endothelial, and hematopoietic origins .
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