Urolithin B
1139-83-9
Urolithin B
Urolithin B is primarily used as a biochemical reference standard or control substance. Concurrently, it is a bioactive molecule of research interest, capable of inhibiting the NF-κB signaling pathway and regulating skeletal muscle mass.
Overview
Urolithin B is a ketone derivative with the chemical name 3-Hydroxy-6H-benzo[C]chromen-6-one.
Its core biological activity lies in modulating key intracellular signaling pathways. It effectively inhibits the transcriptional activity of nuclear factor-kappa B (NF-κB) by reducing the phosphorylation and degradation of the IκBα protein. Furthermore, Urolithin B inhibits the phosphorylation of JNK, ERK, and Akt kinases while enhancing the phosphorylation level of AMPK. These combined actions form the molecular basis for its regulatory effects on cellular functions, particularly its role as a regulator of skeletal muscle mass.
Product Categories: HR140136;novel chemicals;API
Characteristics
Appearance & Form: white to beige powder
Melting Point: 247 °C
Boiling Point: 432.6±24.0 °C (Predicted)
Density: 1.395±0.06 g/cm3 (Predicted)
Storage Temperature: 2-8°C
Solubility: DMSO: soluble 5mg/mL, clear (warmed)
pKa: 9.03±0.20 (Predicted)
LogP: 2.947 (est)
Stability: Hygroscopic
Applications
Based on its well-defined biological activities, Urolithin B is primarily applied in the following scientific research and development fields:
Analytical Chemistry: Serves as a reference standard or control substance for the qualitative and quantitative analysis of urolithins in food analysis, metabolomics, or related biological samples.
Molecular Pharmacology and Biomedical Research:
Used as a tool compound to study the NF-κB signaling pathway and its involvement in inflammation and immune responses.
Employed to investigate the mechanisms of kinase signaling networks (such as JNK, ERK, Akt, and AMPK) in physiological and pathological processes like metabolism and stress response.
Serves as a potential probe molecule for studying skeletal muscle metabolism, atrophy, or regeneration, providing a theoretical basis for developing strategies to intervene in conditions like sarcopenia.
Nutrition and Functional Food Research: As a gut microbiota metabolite (derived from dietary polyphenols like ellagic acid), used to study its potential functions in areas such as healthy aging and sports nutrition.
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