Acetyl zingerone
30881-23-3
Acetyl zingerone
Acetyl zingerone is a novel multifunctional skincare ingredient used to protect melanocytes from ongoing DNA damage and to mitigate skin inflammation. It is incorporated into cosmetic formulations for its antioxidant, anti-inflammatory, and matrix metalloproteinase-inhibiting properties.
Overview
Acetyl zingerone is a synthetic derivative of zingerone, a compound naturally found in ginger, engineered to enhance stability and bioactivity for topical skincare applications. It functions as a multifunctional active ingredient that simultaneously addresses multiple skin concerns. Mechanistically, acetyl zingerone protects melanocytes—the pigment-producing cells in the skin from continuous DNA damage caused by environmental stressors such as UV radiation and pollution. It achieves this by scavenging free radicals and reducing oxidative stress. Additionally, acetyl zingerone inhibits matrix metalloproteinases (MMPs), enzymes responsible for collagen degradation, thereby helping to preserve skin firmness and elasticity. It also suppresses the expression of IL-17A target genes, which are involved in inflammatory pathways, conferring anti-inflammatory benefits. These combined activities—antioxidant, anti-aging (via MMP inhibition), and anti-inflammatory—make acetyl zingerone a promising ingredient for protecting skin health, preventing premature aging, and soothing sensitive or inflamed skin conditions.
EINECS: 820-605-0
Characteristics
Boiling point: 250℃ at 101.325 kPa
Density: 0.494 g/cm3 at 20℃
Vapor pressure: 0 Pa at 25℃
Form: particulate/powder
Pka: 9.87±0.20(Predicted)
LogP: 1.43 at 20℃ and pH 5.99
Surface tension: 61.75 mN/m at 1g/L and 20℃
Applications
1.Anti-aging Skincare: Acetyl zingerone is used in anti-aging formulations to inhibit matrix metalloproteinases, thereby preventing collagen breakdown and reducing the appearance of fine lines and wrinkles. Its antioxidant activity also protects skin cells from UV-induced oxidative damage, helping to maintain a youthful complexion.
2.Anti-inflammatory and Soothing Products: Due to its suppression of IL-17A target genes, acetyl zingerone is incorporated into products designed for sensitive, irritated, or inflammatory skin conditions such as eczema or rosacea. It helps calm redness and discomfort by modulating inflammatory responses.
3.Melanin Protection and Even Skin Tone: By safeguarding melanocytes from DNA damage, acetyl zingerone supports normal melanocyte function and may help prevent hyperpigmentation irregularities caused by environmental stressors. This makes it useful in brightening and tone-evening formulations.
4.Environmental Defense Skincare: The compound's ability to neutralize free radicals and reduce oxidative stress positions it as a key ingredient in products designed to protect against pollution and other environmental aggressors, complementing sunscreens and daily protective lotions.
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