Mitoquinone Bromide

Appearance: Brownish waxy solid or powder at room temperature

Odor: Odorless or no distinct odor reported

Solubility: Soluble in polar organic solvents such as DMSO (up to 70 mg/mL) and ethanol (up to 30 mg/mL); insoluble in non-polar solvents like n-hexane and ether

Storage conditions: Store under dry, sealed, and dark conditions at low temperature (-20°C recommended) to prevent degradation from light, heat, or moisture

1.Mitochondria-Targeted Antioxidant Research: Mitoquinone Bromide is primarily used as a research tool for studying mitochondrial oxidative stress and its role in cellular function and dysfunction. It enables investigators to selectively modulate ROS levels within mitochondria and assess downstream effects on cell signaling, metabolism, and viability.

2.Neurodegenerative Disease Models: The compound is extensively employed in preclinical studies of neurodegenerative conditions including Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), and traumatic brain injury. Its ability to cross the blood-brain barrier and accumulate in neuronal mitochondria makes it valuable for investigating neuroprotective strategies.

3.Oxidative Stress and Aging Research: MitoQ is used to study the role of mitochondrial ROS in aging processes and age-related cellular decline. It helps elucidate mechanisms by which oxidative stress contributes to cellular senescence, DNA damage, and impaired mitochondrial function.

4.Mitochondrial Dysfunction and Metabolic Disorders: Researchers utilize MitoQ in preclinical evaluation of therapies for conditions involving mitochondrial dysfunction, including metabolic syndrome, diabetes, and cardiovascular diseases. It serves as a tool to assess whether mitochondrial ROS contributes to disease pathogenesis and whether targeted antioxidant intervention can ameliorate pathological changes .

5.Organ Preservation and Transplant Research: Studies have demonstrated that MitoQ added to organ preservation solutions protects against cold storage injury in renal tubular cells and rat kidneys by reducing oxidant production, preventing mitochondrial dysfunction, and improving cell viability and tissue morphology . This suggests potential therapeutic applications for reducing organ preservation damage and improving transplant outcomes.

6.Targeted Supplement and Pharmaceutical Development: Mitoquinone Bromide serves as a lead compound for developing targeted nutritional supplements and pharmaceutical agents aimed at enhancing cellular energy production and resilience against oxidative stress.