Spermidine Trihydrochloride

Spermidine Trihydrochloride is the stable, crystalline trihydrochloride salt form of the natural aliphatic polyamine spermidine (white powder at room temperature, far less air-sensitive than the free base liquid), widely recognized as a potent autophagy inducer that triggers histone H3 deacetylation, enhances mitophagy and mitochondrial respiration, and delivers broad cytoprotective effects across species from yeast and worms to flies, mice, and human cells. By inhibiting neuronal nitric oxide synthase (nNOS/NOS1), binding and precipitating DNA, activating T4 polynucleotide kinase and the polyamine modulatory site of the NMDA receptor (acting as an agonist that potentiates NMDA currents), it regulates cellular proliferation, differentiation, stress responses, and synaptic function while preserving nuclei and preventing histone degradation. Extensive studies demonstrate its ability to extend lifespan and healthspan, promote blood vessel relaxation, reduce oxidative stress, improve cardiac elasticity and function, protect neurons against inflammation and toxicity, lower cancer-specific mortality through immune modulation and reduced liver fibrosis/cancer incidence, accelerate wound healing via nitric oxide-releasing formulations that enhance angiogenesis and cell migration, and maintain an excellent safety profile with no genotoxicity and a high NOAEL of 728–829 mg/kg bw/day in 90-day rat studies—positioning Spermidine Trihydrochloride as a versatile, science-backed compound for longevity, metabolic optimization, neuroprotection, and advanced research applications.

EINECS: 206-379-0

Product Categories: Glutamate receptor;Glutamate;334-50-9;1;API