Calcium 2-oxoglutarate

Calcium 2-oxoglutarate is the highly stable calcium salt of 2-oxoglutarate (α-ketoglutarate), a naturally occurring pivotal intermediate in the tricarboxylic acid (Krebs) cycle that drives ATP and GTP production while serving as the primary carbon skeleton for nitrogen-assimilatory reactions across all living organisms. This versatile compound functions as a direct precursor for glutamate synthesis, participates in the biosynthesis of amino acids and fatty acids, modulates cellular transcriptional regulation, and influences plant metabolism, with mitochondria-mediated forms in rat heart tissue shown to precisely control aspartic acid formation. As a reversible tyrosinase inhibitor (IC50 = 15 mM), it offers targeted enzymatic modulation, while its supplementation helps stabilize redox homeostasis, reduce oxidative imbalance, and enhance arterial elasticity—delivering broad biological roles that bridge energy metabolism, amino acid homeostasis, cardiovascular support, and biochemical research, all in a bioavailable salt form prized for laboratory, nutritional, and therapeutic exploration.

EINECS: 275-843-2