Calcium 2-oxoglutarate
71686-01-6
Calcium 2-oxoglutarate
Calcium 2-oxoglutarate is primarily used as a stable calcium salt form of the essential Krebs cycle intermediate to support cellular energy production (ATP/GTP), nitrogen assimilation, glutamate synthesis, and overall metabolic regulation. It is also employed as a reversible tyrosinase inhibitor and for its demonstrated benefits in stabilizing redox homeostasis and improving arterial elasticity in research and nutritional contexts.
概览
Calcium 2-oxoglutarate is the highly stable calcium salt of 2-oxoglutarate (α-ketoglutarate), a naturally occurring pivotal intermediate in the tricarboxylic acid (Krebs) cycle that drives ATP and GTP production while serving as the primary carbon skeleton for nitrogen-assimilatory reactions across all living organisms. This versatile compound functions as a direct precursor for glutamate synthesis, participates in the biosynthesis of amino acids and fatty acids, modulates cellular transcriptional regulation, and influences plant metabolism, with mitochondria-mediated forms in rat heart tissue shown to precisely control aspartic acid formation. As a reversible tyrosinase inhibitor (IC50 = 15 mM), it offers targeted enzymatic modulation, while its supplementation helps stabilize redox homeostasis, reduce oxidative imbalance, and enhance arterial elasticity—delivering broad biological roles that bridge energy metabolism, amino acid homeostasis, cardiovascular support, and biochemical research, all in a bioavailable salt form prized for laboratory, nutritional, and therapeutic exploration.
EINECS: 275-843-2
特点
Melting point:>300°C (not melting)
Storage temp.: -20°C, Hygroscopic
Solubility: Aqueous Acid (Slightly), Water (Slightly, Heated, Sonicated)
Form: Solid
Color: White to Off-White
Water Solubility: Insoluble
Stability: Hygroscopic
应用领域
1.Energy Metabolism and Krebs Cycle Support: Facilitates efficient ATP/GTP generation and cellular energy homeostasis.
2.Nitrogen Assimilation and Amino Acid Synthesis: Provides essential carbon skeleton and serves as precursor for glutamate and related amino acids.
3.Redox Homeostasis and Oxidative Balance: Stabilizes cellular redox state and counters oxidative stress.
4.Cardiovascular and Vascular Health: Improves arterial elasticity and supports mitochondrial regulation of aspartic acid in cardiac tissue.
5.Enzymatic and Research Applications: Acts as reversible tyrosinase inhibitor and valuable intermediate for biochemical, metabolic, and plant science studies.
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