1-Methylnicotinamide chloride
1005-24-9
1-Methylnicotinamide chloride
1-Methylnicotinamide (1-MNA) chloride, an active endogenous metabolite of nicotinamide, is primarily used as a research tool to explore its pharmacological effects of anti-inflammation and antithrombosis. Concurrently, it is employed to study its complex biological effects in modulating tumor angiogenesis and promoting prostacyclin (PGI₂) synthesis.
概览
1-Methylnicotinamide chloride, chemically known as 3-Carbamoyl-1-methylpyridin-1-ium chloride, also termed Trigonellamide chloride, is the active endogenous metabolite of nicotinamide in vivo.
This compound possesses several important biological activities. Its core pharmacological actions are manifested as anti-inflammatory and antithrombotic effects. Furthermore, studies indicate it can enhance tumor vascularization and significantly increase the production of prostacyclin (PGI₂). These properties make it a key bioactive molecule for research in areas such as metabolism, inflammation, thrombosis, and the tumor microenvironment.
EINECS: 463-670-7
Product Categories: Pyridinium Compounds
特点
Appearance & Form: white crystalline
Melting Point: 207-209℃ (water acetone )
Storage Temperature: room temp
Solubility: H2O: soluble 15mg/mL, clear
Water Solubility: Soluble, almost transparency
应用领域
Based on its defined biological activities, 1-Methylnicotinamide chloride is primarily applied as a research compound in the following biomedical fields:
Inflammation & Immunology Research: Used as a tool molecule to investigate its mechanisms of action in models of chronic inflammatory diseases.
Cardiovascular & Thrombosis Research: Employed to explore the molecular pathways of its antithrombotic effects and the mechanisms by which it regulates vascular tone and platelet function through promoting prostacyclin (PGI₂) generation.
Cancer Biology Research: Used to study how endogenous metabolites influence tumor angiogenesis and the tumor microenvironment, providing insights into cancer metabolism.
Metabolism & Nutrition Research: Serves as a marker or effector molecule of the nicotinamide metabolic pathway for studying the relationship between vitamin B₃ metabolism and health or disease states.
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